Invention Grant
- Patent Title: Modulation of BCL11A for treatment of hemoglobinopathies
- Patent Title (中): 调节BCL11A治疗血红蛋白病
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Application No.: US13063524Application Date: 2009-09-14
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Publication No.: US08383604B2Publication Date: 2013-02-26
- Inventor: Stuart H. Orkin , Vijay G. Sankaran
- Applicant: Stuart H. Orkin , Vijay G. Sankaran
- Applicant Address: US MA Boston US MA Cambridge
- Assignee: Children's Medical Center Corporation,President and Fellows of Harvard College
- Current Assignee: Children's Medical Center Corporation,President and Fellows of Harvard College
- Current Assignee Address: US MA Boston US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Tari W. Mills
- International Application: PCT/US2009/056770 WO 20090914
- International Announcement: WO2010/030963 WO 20100318
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N5/071 ; C07H21/02 ; C07K14/00
Abstract:
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.
Public/Granted literature
- US20110182867A1 MODULATION OF BCL11A FOR TREATMENT OF HEMOGLOBINOPATHIES Public/Granted day:2011-07-28
Information query
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