Invention Grant
US08383108B2 Therapeutic uses of monoclonal antibodies to the angiotensin-II type 1 receptor
有权
对血管紧张素-II 1型受体的单克隆抗体的治疗用途
- Patent Title: Therapeutic uses of monoclonal antibodies to the angiotensin-II type 1 receptor
- Patent Title (中): 对血管紧张素-II 1型受体的单克隆抗体的治疗用途
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Application No.: US13087770Application Date: 2011-04-15
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Publication No.: US08383108B2Publication Date: 2013-02-26
- Inventor: Gavin Paul Vinson , John Richard Puddefoot , Stewart Barker
- Applicant: Gavin Paul Vinson , John Richard Puddefoot , Stewart Barker
- Applicant Address: GB London
- Assignee: Queen Mary & Westfield College, University of London
- Current Assignee: Queen Mary & Westfield College, University of London
- Current Assignee Address: GB London
- Agency: Pepper Hamilton, LLP
- Priority: GB0219524.6 20020821
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K35/12
Abstract:
The use of monoclonal antibodies to the angiotensin-II type-I receptor is provided for the treatment of cancer and vascular smooth muscle cell proliferation. Specifically, use is provided of a monoclonal antibody or a fragment thereof to a peptide comprising the N-terminal portion of the angiotensin-II type-1 receptor defined by the sequence MILNSSTEDG IKRIQDDCPK AGHRHNYIFVM IPTLYSIIFV VGIFG in the preparation of a medicament for the treatment of cancer or in the preparation of a medicament for the treatment of vascular smooth muscle (VSM) cell proliferation.
Public/Granted literature
- US20110256139A1 Therapeutic Uses Of Monoclonal Antibodies To The Angiotensin-II Type 1 Receptor Public/Granted day:2011-10-20
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