An information storage medium and a method and apparatus for recording/reproducing data on/from the information storage medium. The information storage medium includes a plurality of recording layers, each having a user data area, on which data can be recorded by a pickup. Data is recorded in the order of recording layers from closest to farthest from the pickup, and a recordable region in a user data area of a recording layer on which data is to be recorded is smaller than that in a recording layer between the pickup and the recording layer on which data is to be recorded. Each recording layer contains a recordable region in a user data area and a optimum power control (OPC) area in order to maintain the same recording/reproducing characteristics between the plurality of recording layers.