A screen protector applicator includes a cradle having a bottom surface, a plurality of upstanding peripheral walls and an open top in communication with an interior chamber. The interior chamber is dimensioned and configured to tightly conform to the periphery of both an adhesive screen protector and a corresponding portable electronic device, such as a wireless phone. The protector includes an earpiece slit adjacent a top edge and a control button aperture proximal a lower edge that respectively align with a protrusion and a mound on the bottom surface of the cradle. To apply the screen protector, a user positions the protector within the cradle such that the protrusion is seated in the slit and the mound is received within the aperture. A protective layer on the film is removed to expose an adhesive, and the electronic device is superimposed, face-down, on the anchored film to adhesively bond the device thereto.