Systems and methodologies for adapting input/output operation of an electronic device for left-handed and/or right-handed scenarios are provided herein. As described herein, sensors (e.g., capacitive, resistive, touch-sensitive, etc.) are applied to respective outer edges of a device to determine whether a device is in a user's left hand and/or right hand. Based on this determination, respective points along the sensors can be mapped to soft keys to automatically optimize input for left-handed and/or right-handed operation. As further described herein, points of contact with an input device such as a touch-screen can be corrected based on whether a user's left hand and/or right hand is holding an associated electronic device. For example, upon identifying contact between a touch-screen and a thumb of a hand being used to hold an associated device, the point of contact can be shifted to compensate for the angle of the thumb with respect to the touch-screen.