An imaging reader for electro-optically reading a target by image capture includes a window supported by a housing, a chassis mounted in the housing and having chassis walls bounding an optical compartment, and an imaging module in the optical compartment for capturing return light from the target through the window. A component seals the optical compartment and protects the window from shock forces. The component is mounted between the window and the chassis walls bounding an opening into the optical compartment, and surrounds a periphery of the window. The component is constituted of a compressible material that is compressed between the window and the chassis walls to isolate and seal the optical compartment from the housing.