Invention Grant
- Patent Title: Pyridinone antagonists of alpha-4 integrins
- Patent Title (中): α-4整联蛋白的吡啶酮拮抗剂
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Application No.: US12768680Application Date: 2010-04-27
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Publication No.: US08367836B2Publication Date: 2013-02-05
- Inventor: Ying-zi Xu , Shendong Yuan , David Wone , Andrei Konradi
- Applicant: Ying-zi Xu , Shendong Yuan , David Wone , Andrei Konradi
- Applicant Address: US CA South San Francisco
- Assignee: Elan Pharmaceuticals, Inc.
- Current Assignee: Elan Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Foley & Lardner LLP
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D401/12 ; C07D213/02 ; A61K31/4412
Abstract:
The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula: or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2, R3, R4, R5 and R6 are defined in the specification. The invention further provides pharmaceutical compositions including the compounds of the invention as well as methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various conditions and disorders, such as Crohn's disease and ulcerative colitis.
Public/Granted literature
- US20110009407A1 PYRIDINONE ANTAGONISTS OF ALPHA-4 INTEGRINS Public/Granted day:2011-01-13
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