Invention Grant
US08367816B2 Compositions and methods for the treatment of sepsis and other disorders involving phospholipase A2 induction
失效
用于治疗败血症和涉及磷脂酶A2诱导的其它病症的组合物和方法
- Patent Title: Compositions and methods for the treatment of sepsis and other disorders involving phospholipase A2 induction
- Patent Title (中): 用于治疗败血症和涉及磷脂酶A2诱导的其它病症的组合物和方法
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Application No.: US13265842Application Date: 2010-03-25
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Publication No.: US08367816B2Publication Date: 2013-02-05
- Inventor: Maw-Shung Liu
- Applicant: Maw-Shung Liu
- Agent Martin L. McGregor
- International Application: PCT/US2010/028622 WO 20100325
- International Announcement: WO2010/123648 WO 20101028
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K48/00
Abstract:
The present invention provides antisense oligomers to PLA2 to inhibit PLA2 protein expression and enzyme activity, and to treat diseases and disorders associated with induced expression of PLA2. In particular, the invention provides for the simultaneous inhibition of cPLA2 and sPLA2.
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