Invention Grant
- Patent Title: Fc variants with altered binding to FcRn
- Patent Title (中): Fc变体与FcRn结合改变
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Application No.: US12341769Application Date: 2008-12-22
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Publication No.: US08367805B2Publication Date: 2013-02-05
- Inventor: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agency: Morgan, Lewis & Bockius, LLP
- Agent Robin M. Silva; Gargi Talukder
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P218/08 ; A61K39/395 ; A61K39/40 ; A61K39/42 ; C07K1/00
Abstract:
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
Public/Granted literature
- US20090163699A1 Fc VARIANTS WITH ALTERED BINDING TO FcRn Public/Granted day:2009-06-25
Information query
