Invention Grant
- Patent Title: High affinity NY-ESO T cell receptors
- Patent Title (中): 高亲和力的NY-ESO T细胞受体
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Application No.: US13176090Application Date: 2011-07-05
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Publication No.: US08367804B2Publication Date: 2013-02-05
- Inventor: Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
- Applicant: Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn , Lucy Boulter
- Applicant Address: GB Oxon
- Assignee: Immunocore Limited
- Current Assignee: Immunocore Limited
- Current Assignee Address: GB Oxon
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Smitha B. Uthaman
- Priority: GB0411123.3 20040519; GB0419643.2 20040903
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K17/00
Abstract:
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
Public/Granted literature
- US20110262414A1 HIGH AFFINITY NY-ESO T CELL RECEPTORS Public/Granted day:2011-10-27
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