Invention Grant
- Patent Title: Method for inhibiting expression of a protein in a hepatocyte
- Patent Title (中): 抑制肝细胞中蛋白质表达的方法
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Application No.: US12550109Application Date: 2009-08-28
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Publication No.: US08367630B2Publication Date: 2013-02-05
- Inventor: Xianbin Tian , Peijin Zhang , Kim L. R. Brouwer
- Applicant: Xianbin Tian , Peijin Zhang , Kim L. R. Brouwer
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12P19/34 ; C12Q1/68
Abstract:
A method of screening a candidate compound for susceptibility to biliary excretion by a hepatocyte transport protein. In some embodiments the method can comprise inhibiting expression of the transport protein. Expression of the transport protein can be inhibited through introduction of a RNA having a sequence corresponding to a coding strand of the gene encoding the transport protein into the hepatocyte.
Public/Granted literature
- US20090325297A1 METHOD FOR INHIBITING EXPRESSION OF A PROTEIN IN A HEPATOCYTE Public/Granted day:2009-12-31
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