Invention Grant
US08367619B2 Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression
有权
通过增加托普拉斯汀的表达来促进弹性变形和弹性蛋白纤维形成的方法
- Patent Title: Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression
- Patent Title (中): 通过增加托普拉斯汀的表达来促进弹性变形和弹性蛋白纤维形成的方法
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Application No.: US12526625Application Date: 2008-02-07
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Publication No.: US08367619B2Publication Date: 2013-02-05
- Inventor: Thomas N. Wight , Mervyn Merrilees
- Applicant: Thomas N. Wight , Mervyn Merrilees
- Applicant Address: US WA Seattle
- Assignee: Benaroya Research Institute at Virginia Mason
- Current Assignee: Benaroya Research Institute at Virginia Mason
- Current Assignee Address: US WA Seattle
- Agency: Seed IP Law Group PLLC
- International Application: PCT/US2008/053341 WO 20080207
- International Announcement: WO2008/100789 WO 20080821
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/00 ; C12N5/00 ; C12N5/02 ; A61P43/00 ; A61P19/00 ; A61P17/00
Abstract:
Compositions and methods are provided for promoting elastin fiber formation (elastogenesis) in a cell, including methods that comprise contacting a cell that is capable of elastogenesis with (i) a mutated biglycan polypeptide that lacks chondroitin sulphate proteoglycan chains, (ii) a versican V3 isoform polypeptide that lacks most or all of the polypeptide regions encoded by one or more of exons 4, 5 or 6 or by exons 9-10 or 11-13, and/or with (iii) metastatin.
Public/Granted literature
- US20100197563A1 COMPOSITIONS AND METHODS FOR ALTERING ELASTOGENESIS Public/Granted day:2010-08-05
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