Invention Grant
US08367407B2 Cells with altered fucosylation and producing antibodies therefrom
有权
具有改变的岩藻糖基化并由此产生抗体的细胞
- Patent Title: Cells with altered fucosylation and producing antibodies therefrom
- Patent Title (中): 具有改变的岩藻糖基化并由此产生抗体的细胞
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Application No.: US12409587Application Date: 2009-03-24
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Publication No.: US08367407B2Publication Date: 2013-02-05
- Inventor: Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
- Applicant: Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
- Applicant Address: JP Tokyo
- Assignee: Kyowa Hakko Kirin Co., Ltd.
- Current Assignee: Kyowa Hakko Kirin Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JPP2000-308526 20001006; WOPCT/JP01/08804 20011005
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N5/16 ; C12N5/00 ; C12N5/02 ; C12N5/10
Abstract:
The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.
Public/Granted literature
- US20090228994A1 Antibody Composition-Producing Cell Public/Granted day:2009-09-10
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