Invention Grant
US08367374B2 Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
有权
融合构建体及其使用以产生具有增加的Fc受体结合亲和力和效应子功能的抗体
- Patent Title: Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
- Patent Title (中): 融合构建体及其使用以产生具有增加的Fc受体结合亲和力和效应子功能的抗体
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Application No.: US10761435Application Date: 2004-01-22
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Publication No.: US08367374B2Publication Date: 2013-02-05
- Inventor: Pablo Umaña , Peter Bruenker , Claudia Ferrara , Tobias Suter
- Applicant: Pablo Umaña , Peter Bruenker , Claudia Ferrara , Tobias Suter
- Applicant Address: CH
- Assignee: Roche GlycArt AG
- Current Assignee: Roche GlycArt AG
- Current Assignee Address: CH
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C12P21/04
- IPC: C12P21/04 ; C12P21/08
Abstract:
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
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