Invention Grant
US08367052B2 Methods for promoting protection and regeneration of bone marrow using CXCL9 and anti-CXCL9 antibodies
有权
使用CXCL9和抗CXCL9抗体促进骨髓保护和再生的方法
- Patent Title: Methods for promoting protection and regeneration of bone marrow using CXCL9 and anti-CXCL9 antibodies
- Patent Title (中): 使用CXCL9和抗CXCL9抗体促进骨髓保护和再生的方法
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Application No.: US12530579Application Date: 2007-03-26
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Publication No.: US08367052B2Publication Date: 2013-02-05
- Inventor: Wei Han , Huili Lu
- Applicant: Wei Han , Huili Lu
- Applicant Address: KY Grand Cayman
- Assignee: General Regeneratives Holdings Inc.
- Current Assignee: General Regeneratives Holdings Inc.
- Current Assignee Address: KY Grand Cayman
- Agency: Foley & Lardner LLP
- International Application: PCT/CN2007/000971 WO 20070326
- International Announcement: WO2008/116347 WO 20081002
- Main IPC: A61K38/19
- IPC: A61K38/19 ; A61K45/00 ; A61K39/395 ; C07K14/435 ; C07K14/475 ; C07K14/52 ; C07K16/24
Abstract:
CXCL9 promotes bone marrow regeneration, increases peripheral white blood cells, and increases survival if administered prior to treatment of a subject with chemotherapeutic drugs such as 5-FU or radiotherapy. Similar effects are obtained by administering an anti-CXCL9 antibody following chemotherapy or radiotherapy. Compositions and methods are presented for the treatment of cancer and bone marrow diseases.
Public/Granted literature
- US20100040603A1 METHODS FOR PROMOTING PROTECTION AND REGENERATION OF BONE MARROW USING CXCL9 AND ANTI-CXCL9 ANTIBODIES Public/Granted day:2010-02-18
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