Invention Grant
US08367039B2 Compounds for the diagnosis of diseases associated with VCAM expression
有权
用于诊断与VCAM表达相关的疾病的化合物
- Patent Title: Compounds for the diagnosis of diseases associated with VCAM expression
- Patent Title (中): 用于诊断与VCAM表达相关的疾病的化合物
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Application No.: US12593175Application Date: 2008-03-28
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Publication No.: US08367039B2Publication Date: 2013-02-05
- Inventor: Marc Port , Olivier Rousseaux , Robert Muller , Carmen Burtea
- Applicant: Marc Port , Olivier Rousseaux , Robert Muller , Carmen Burtea
- Applicant Address: FR Villepinte
- Assignee: Guerbet
- Current Assignee: Guerbet
- Current Assignee Address: FR Villepinte
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FR0754087 20070328
- International Application: PCT/EP2008/053768 WO 20080328
- International Announcement: WO2008/125464 WO 20081023
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
The present invention relates to a compound of the following general formula (I): Signal-Linker-Peptide (I) in which Signal is a signal entity; Linker, is absent or is a chemical bond, and Peptide is a peptide having a VCAM-targeting peptide and pharmaceutically acceptable salts thereof. The VCAM-targeting peptide may be X10-X11-X12-X13-X14-X15-X16-X17-X18 (SEQ ID No. 4) with X10 chosen from cysteine and methionine; X11 chosen from methionine and cysteine; X12 chosen from lysine, arginine and alanine; X13 chosen from threonine and serine; X14 chosen from aspartic acid and glutamic acid; X15 chosen from threonine and serine; X16 chosen from arginine, alanine and lysine; X17 chosen from leucine, isoleucine and valine; X18 chosen from cysteine and methionine; preferably, the peptide CMKTDTRLC (SEQ ID No. 5).
Public/Granted literature
- US20110200533A1 COMPOUNDS FOR THE DIAGNOSIS OF DISEASES ASSOCIATED WITH VCAM EXPRESSION Public/Granted day:2011-08-18
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