Aspects of a method and system for utilizing direct digital frequency synthesis in multi-band applications are provided. A direct digital frequency synthesizer integrated in a multiband wireless receiver chip may be enabled to generate one or more reference signals that may be utilized to down-convert VHF, UHF and L-band signals to baseband signals. The direct digital frequency synthesizer may further generate one or more reference signals, which may be utilized to calibrate one or more circuits that process received VHF, UHF, and L-band signals. In this regard, the signals generated by the direct digital frequency synthesizer may be utilized to calibrate one or more LNAs in a receive processing chain of the chip and/or one or more filters that may be utilized to process baseband signals.