Systems and methods are provided to facilitate the distribution of audio signals over wireless networks. In one implementation, an audio system includes a head end having an encoder and a wireless network interface. Audio signals associated with a plurality of audio channels are processed by the encoder to provide an encoded signal in accordance with an audio codec. The encoded signal can be provided to a wireless network by the wireless network interface as a plurality of data packets associated with a network address in accordance with a wireless networking protocol, such as an IEEE 802.11 protocol. One or more remote endpoints can also be provided to receive the data packets from the wireless network, assemble the data packets to obtain the encoded signal, and extract at least one of the audio signals from the encoded signal in accordance with the audio codec. Multicast and unicast implementations are also provided.