Image sensor, which comprises a plurality of pixels arranged as a pixel array with rows and columns and at least one read-out arrangement for reading out the pixels row by row. The columns are grouped into blocks with a certain number N of columns. Each read-out arrangement comprises N column read out circuits and an addressing circuit for with at least two groups of addressing lines for addressing the blocks. The blocks are selectively addressed by the groups of addressing lines in a way that a read-out sequence of blocks addressed by the groups is continuous across all blocks.