The present invention provides a sealed optoelectronic isolation connection device which comprises an insulation cylinder, an optical fiber sealing device, and a conduit sealing device; the insulation cylinder is configured to insulate the conduit sealing device and the optical fiber sealing device; the conduit sealing device is provided with a conduit hole, which is configured to accommodate a conduit of an optical cable and sealing the conduit; the optical fiber sealing device is provided with multiple optical fiber holes, which are configured to accommodate optical fibers of the optical cable and sealing the optical fibers; and the optical fiber sealing device and the conduit sealing device are inserted in sequence into the insulation cylinder and seal the insulation cylinder. The device enhances the reliability of the sealed optoelectronic isolation connection device.