The invention relates to a method of processing temporally acquired image data with an obtaining step for obtaining the temporally acquired image data, a computing step for computing a time-variability map on the basis of the temporally acquired image data, a classifying step for classifying locations of the temporally acquired image data on the basis of the time-variability map, and a determining step for determining an artifact region and a non-artifact region in the temporally acquired image data on the basis of the classified locations. After determining the artifact region and the non-artifact region, detecting an object in a detecting step is limited to the non-artifact region. This advantageously reduces the risk of falsely identifying the detected object as an object of interest.