Invention Grant
- Patent Title: Isoindolin-1-one derivatives
- Patent Title (中): 异吲哚啉-1-酮衍生物
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Application No.: US11574531Application Date: 2005-08-26
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Publication No.: US08258175B2Publication Date: 2012-09-04
- Inventor: Hendrika Maria Gerarda Willems , Per Kallblad , Ian Robert Hardcastle , Roger John Griffin , Bernard Thomas Golding , John Lunec , Martin E. M. Noble , David R. Newell , Alan H. Calvert
- Applicant: Hendrika Maria Gerarda Willems , Per Kallblad , Ian Robert Hardcastle , Roger John Griffin , Bernard Thomas Golding , John Lunec , Martin E. M. Noble , David R. Newell , Alan H. Calvert
- Applicant Address: GB London
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB London
- Agency: Notaro, Michalos & Zaccaria P.C.
- Priority: GB0419481.7 20040902
- International Application: PCT/GB2005/003345 WO 20050826
- International Announcement: WO2006/024837 WO 20060309
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; C07D209/46

Abstract:
A compound of formula or a prodrug and/or a pharmaceutically acceptable salt thereof, wherein X is O, N or S; R1 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; R2 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; R3 is hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; and R4-R7, is used to represent groups R4, R5, R6 and R7 which are H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, halo, CF3, NH2, NO2, COOH, C═O.
Public/Granted literature
- US20080261917A1 Isoindolin-1-One Derivatives Public/Granted day:2008-10-23
Information query
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