Invention Grant
US08258108B2 Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
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Ras灭活激酶抑制剂治疗Ras介导的肿瘤发生
- Patent Title: Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
- Patent Title (中): Ras灭活激酶抑制剂治疗Ras介导的肿瘤发生
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Application No.: US11974473Application Date: 2007-10-12
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Publication No.: US08258108B2Publication Date: 2012-09-04
- Inventor: Richard N. Kolesnick , Hongmei R. Xing
- Applicant: Richard N. Kolesnick , Hongmei R. Xing
- Applicant Address: US NY New York
- Assignee: Memorial Sloan-Kettering Cancer Center
- Current Assignee: Memorial Sloan-Kettering Cancer Center
- Current Assignee Address: US NY New York
- Agency: Klauber & Jackson LLC
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gfRas mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
Public/Granted literature
- US20080096840A1 Kinase supressor of Ras inactivation for therapy of Ras mediated tumorigenesis Public/Granted day:2008-04-24
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