Systems and methods for providing contextual advertisements to present to a user in association with electronic books are provided. Advertising entities may submit information to include in the contextual e-book advertisement. An advertisement manager identifies the e-book and content associated with each page therein. A target page to receive the advertisement is identified. The contextual e-book advertisement is generated using content associated with the target page as well as content associated with each page preceding the target page. Content associated with pages subsequent to the target page is analyzed to determine if the advertisement is appropriate for the target page. Additional sequential information and user profile information may be used to generate the contextual e-book advertisement. Based on the content of the e-book and the parameters of the information submitted by the advertising entity, a contextual e-book advertisement is generated for the target page and presented to a user.