Mitigating interference in a mobile wireless communication device by using an estimation of the performance impact of interfering signals generated by a wireless cellular transmitter and received by a co-located Bluetooth receiver. Bluetooth frequency channels are marked suitable or unsuitable for transmission based on the performance impact estimation and the state of the wireless cellular and Bluetooth connections. The estimation accounts for properties of the wireless cellular transmitter and Bluetooth receiver as well as operational characteristics of the wireless cellular and Bluetooth connections.