X-ray collimators, and related systems and methods involving such collimators are provided. In this regard, a representative X-ray collimator includes: a first member having channels located on a surface thereof; and a second member having protrusions located on a surface thereof; the first member and the second member being oriented such that the protrusions extend into the channels to define collimator apertures, each of the collimator apertures being defined by a portion of the first member and a portion of the second member.