A communication system includes first and second independently clocked devices, comprising, for each device, a transmitter and a receiver connected to each other in a crossed way in correspondence of an inter-chip communication channel. The communication system further comprises a synchronizer in turn including at least a first and a second synchronization block, having respective input terminals connected to the receivers and respective output terminals connected to the transmitters and comprising at least: a test pattern generator that generates a programmable test pattern signal; a pattern detector to check a matching between stored and received test pattern signals and thus lock corresponding clock phases of the synchronization blocks in case of positive result of this check; and a delay block able to change the clock phases until a synchronized condition of the synchronization blocks is verified, this synchronized condition corresponding to a matching between stored and received test pattern signals.