A method and apparatus to set printer driver information. The method includes detecting identification information to identify printer setup information selected in an application program, detecting a printer driver information corresponding to the detected identification information, and setting and storing the selected printer setup information as printer setup information of the detected printer driver information. When the user selects the printer setup information in a specific application program, the printer setup information setup in a printer folder is set as the printer setup information selected by the user. Specifically, when the user selects the default printer in the specific application program, the default printer of the printer driver information is set as the default printer selected by the user, so that the setup information selected in the application program is maintained as the printer driver information even after the application program is terminated.