A system and method of clock generation to provide divided-by-2 clocks with prescribed phase shifts are disclosed. In a communication system with high-order harmonic mixing, the system requires LO signals with a set of prescribed phase shifts, such as 0°, 45°, 90°, and 135°, or 0°, 60° and 120°. Often, the clock generation system involves a divide-by-2 divider to derive the clock signals with the prescribed phase shifts. In a conventional implementation of the divide-by-2 divider, the system is subject to phase uncertainty in the output signal. Accordingly, a system comprises multiple latch pairs and respective differential clocks are used to generate the clocks with the set of correct prescribed phase shifts.