Invention Grant
- Patent Title: Cyclopamine analogues and methods of use thereof
- Patent Title (中): 环戊胺类似物及其使用方法
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Application No.: US12969024Application Date: 2010-12-15
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Publication No.: US08236956B2Publication Date: 2012-08-07
- Inventor: Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
- Applicant: Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
- Applicant Address: US MA Cambridge
- Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fish & Richardson P.C.
- Main IPC: C07D491/048
- IPC: C07D491/048 ; C07D491/04
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
Public/Granted literature
- US20110166353A1 Cyclopamine Analogues and Methods of Use Thereof Public/Granted day:2011-07-07
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