Invention Grant
- Patent Title: Multi-cyclic compounds and methods of use
- Patent Title (中): 多环化合物和使用方法
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Application No.: US11977970Application Date: 2007-10-25
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Publication No.: US08236823B2Publication Date: 2012-08-07
- Inventor: Brian L. Hodous , Stephanie D. Geuns-Meyer , Philip R. Olivieri , Vinod F. Patel
- Applicant: Brian L. Hodous , Stephanie D. Geuns-Meyer , Philip R. Olivieri , Vinod F. Patel
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent G. Prabhakar Reddy
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D401/04
Abstract:
The present invention relates to compounds of Formulas I and II, wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.
Public/Granted literature
- US20080255205A1 Multi-cyclic compounds and methods of use Public/Granted day:2008-10-16
Information query
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