Invention Grant
- Patent Title: Pyrazine derivatives as ENAC blockers
- Patent Title (中): 吡嗪衍生物作为ENAC阻断剂
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Application No.: US12995647Application Date: 2009-06-08
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Publication No.: US08236808B2Publication Date: 2012-08-07
- Inventor: Stephen Paul Collingwood , Nicholas James Devereux , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt
- Applicant: Stephen Paul Collingwood , Nicholas James Devereux , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Mark W. Milstead
- Priority: EP08157980 20080610
- International Application: PCT/EP2009/057060 WO 20090608
- International Announcement: WO2009/150137 WO 20091217
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; C07D241/20
Abstract:
A compound of Formula I or a hydrate or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
Public/Granted literature
- US20110201625A1 Organic Comopunds Public/Granted day:2011-08-18
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