Invention Grant
- Patent Title: Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
- Patent Title (中): 喹喔啉基大环丙型肝炎丝氨酸蛋白酶抑制剂
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Application No.: US12505725Application Date: 2009-07-20
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Publication No.: US08236807B2Publication Date: 2012-08-07
- Inventor: Suanne Nakajima , Zhenwei Miao , Ying Sun , Datong Tang , Guoyou Xu , Brian Porter , Yat Sun Or , Zhe Wang
- Applicant: Suanne Nakajima , Zhenwei Miao , Ying Sun , Datong Tang , Guoyou Xu , Brian Porter , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D409/14 ; A61K31/38 ; A61K31/395 ; A61P31/12
Abstract:
The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Public/Granted literature
- US20100015092A1 QUINOXALINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS Public/Granted day:2010-01-21
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