Invention Grant
- Patent Title: Uses of synthetic peptide amides
- Patent Title (中): 合成肽酰胺的用途
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Application No.: US12480059Application Date: 2009-06-08
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Publication No.: US08236766B2Publication Date: 2012-08-07
- Inventor: Claudio D. Schteingart , Frederique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
- Applicant: Claudio D. Schteingart , Frederique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
- Applicant Address: US CT Shelton
- Assignee: Cara Therapeutics, Inc.
- Current Assignee: Cara Therapeutics, Inc.
- Current Assignee Address: US CT Shelton
- Agency: F. Chau & Associates LLC
- Agent Algis Anilionis
- Main IPC: A61K38/07
- IPC: A61K38/07
Abstract:
The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: wherein Xaa is a D-amino acid and G is selected from the following three groups: The compounds are useful in the prophylaxis and treatment of pain, pruritus and inflammation associated with a variety of diseases and conditions.
Public/Granted literature
- US20100075910A1 SYNTHETIC PEPTIDE AMIDES AND DIMERIC FORMS THEREOF Public/Granted day:2010-03-25
Information query
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