Invention Grant
US08236751B2 Methods of increasing muscle mass using follistatin-like related gene (FLRG)
有权
使用卵泡抑素样相关基因（FLRG）增加肌肉质量的方法
- Patent Title: Methods of increasing muscle mass using follistatin-like related gene (FLRG)
- Patent Title (中): 使用卵泡抑素样相关基因（FLRG）增加肌肉质量的方法
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Application No.: US12529179Application Date: 2008-03-06
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Publication No.: US08236751B2Publication Date: 2012-08-07
- Inventor: Se-Jin Lee
- Applicant: Se-Jin Lee
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: DLA Piper LLP (US)
- International Application: PCT/US2008/056098 WO 20080306
- International Announcement: WO2008/109779 WO 20080912
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K48/00 ; A61K39/395 ; A61K39/00 ; C12N15/11
Abstract:
The present relates to use of follistatin-like related gene (FLRG) to increase muscle mass in a subject. As such, methods of ameliorating the severity of a pathologic condition characterized, at least in part, by a decreased amount, development or metabolic activity of muscle are provided. In addition transgenic non-human mammals expressing FLRG and having increased muscle mass as compared to a corresponding mammal having a myostatin-null mutation or a decreased level of myostatin are provided.
Public/Granted literature
- US20100169989A1 Use of Follistatin-Like Related Gene (FLRG) to Increase Muscle Mass Public/Granted day:2010-07-01
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