Invention Grant
US08236572B2 Chemical exchange saturation transfer based MRI using reporter genes and MRI methods related thereto
有权
使用报告基因的化学交换饱和转运基于MRI的MRI方法
- Patent Title: Chemical exchange saturation transfer based MRI using reporter genes and MRI methods related thereto
- Patent Title (中): 使用报告基因的化学交换饱和转运基于MRI的MRI方法
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Application No.: US11883533Application Date: 2006-02-07
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Publication No.: US08236572B2Publication Date: 2012-08-07
- Inventor: Peter C. M. van Zijl , Assaf A. Gilad , Jeff Bulte , Michael T. Mcmahon , Raman Venu , Paul T. Winnard, Jr.
- Applicant: Peter C. M. van Zijl , Assaf A. Gilad , Jeff Bulte , Michael T. Mcmahon , Raman Venu , Paul T. Winnard, Jr.
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless
- International Application: PCT/US2006/004187 WO 20060207
- International Announcement: WO2006/086343 WO 20060817
- Main IPC: G01N24/00
- IPC: G01N24/00
Abstract:
Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes chemical exchange saturation transfer (CEST) technique for imaging.
Public/Granted literature
- US20080284427A1 Chemical Exchange Saturation Transfer Based Mri Using Reporter Genes and Mri Methods Related Thereto Public/Granted day:2008-11-20
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