Invention Grant
US08236518B2 Highly sensitive immunoassays and antibodies for detection of blood factor VIII
有权
用于检测血液因子VIII的高度灵敏的免疫测定和抗体
- Patent Title: Highly sensitive immunoassays and antibodies for detection of blood factor VIII
- Patent Title (中): 用于检测血液因子VIII的高度灵敏的免疫测定和抗体
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Application No.: US11988518Application Date: 2006-07-13
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Publication No.: US08236518B2Publication Date: 2012-08-07
- Inventor: Behnaz Parhami-Seren , Kenneth G. Mann , David N. Fass
- Applicant: Behnaz Parhami-Seren , Kenneth G. Mann , David N. Fass
- Applicant Address: US VT Burlington
- Assignee: The University of Vermont and State Agriculture College
- Current Assignee: The University of Vermont and State Agriculture College
- Current Assignee Address: US VT Burlington
- Agency: Edwards Wildman Palmer LLP
- Agent David G. Conlin; Elbert Chiang
- International Application: PCT/US2006/027409 WO 20060713
- International Announcement: WO2007/011746 WO 20070125
- Main IPC: C12Q1/56
- IPC: C12Q1/56 ; G01N33/53 ; G01N33/86
Abstract:
Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment of blood coagulation disorders, and determination of FVIII levels in plasma of human patients, including those with blood coagulation disorders such as hemophilia.
Public/Granted literature
- US20090215070A1 Highly Sensitive Immunoassays and Antibodies for Detection of Blood Factor VIII Public/Granted day:2009-08-27
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