Invention Grant
US08236506B2 Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the KLK8 gene encoding kallikrein 8 and use thereof for prognosticating survival
有权
通过检测编码激肽释放酶8的KLK8基因的主要替代转录物进行体外诊断支气管肺癌的方法及其在预后中的应用
- Patent Title: Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the KLK8 gene encoding kallikrein 8 and use thereof for prognosticating survival
- Patent Title (中): 通过检测编码激肽释放酶8的KLK8基因的主要替代转录物进行体外诊断支气管肺癌的方法及其在预后中的应用
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Application No.: US12310622Application Date: 2007-09-27
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Publication No.: US08236506B2Publication Date: 2012-08-07
- Inventor: Mireille Ainciburu , Yves Courty , Colette Jolivet-Reynaud , Chris Planque
- Applicant: Mireille Ainciburu , Yves Courty , Colette Jolivet-Reynaud , Chris Planque
- Applicant Address: FR Marcy l'Etoile FR Tours
- Assignee: Biomerieux,Universite Francois Rabelais
- Current Assignee: Biomerieux,Universite Francois Rabelais
- Current Assignee Address: FR Marcy l'Etoile FR Tours
- Agency: Oliff & Berridge, PLC
- Priority: FR0653983 20060928
- International Application: PCT/FR2007/052023 WO 20070927
- International Announcement: WO2008/037930 WO 20080403
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to a method for the in vitro diagnosis of bronchopulmonary carcinoma, in particular of non-small cell bronchial carcinoma, characterized in that it comprises the stage of detecting, in a biological sample derived from a patient suspected to be suffering from said bronchopulmonary carcinoma, at least one of the major alternative transcripts of the KLK8 gene encoding kallikrein 8. This method is particularly useful for the survival prognostication of patients suffering from bronchopulmonary carcinoma.
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