Invention Grant
US08236327B2 Modified flagellin improved toll-like receptor 5 stimulating activity
有权
改良的鞭毛蛋白改善了toll样受体5刺激活性
- Patent Title: Modified flagellin improved toll-like receptor 5 stimulating activity
- Patent Title (中): 改良的鞭毛蛋白改善了toll样受体5刺激活性
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Application No.: US12526187Application Date: 2009-08-06
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Publication No.: US08236327B2Publication Date: 2012-08-07
- Inventor: Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim
- Applicant: Joon Haeng Rhee , Shee Eun Lee , Soo Young Kim
- Applicant Address: KR Gwangju
- Assignee: Industry Foundation of Chonnam National University
- Current Assignee: Industry Foundation of Chonnam National University
- Current Assignee Address: KR Gwangju
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2007-0013846 20070209; KR10-2008-0011330 20080204
- Main IPC: A61K39/106
- IPC: A61K39/106
Abstract:
Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
Public/Granted literature
- US20110008378A1 MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY Public/Granted day:2011-01-13
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