Invention Grant
- Patent Title: Compositions and methods of using chondroitinase ABCI mutants
- Patent Title (中): 使用软骨素酶ABCI突变体的组成和方法
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Application No.: US12757006Application Date: 2010-06-04
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Publication No.: US08236302B2Publication Date: 2012-08-07
- Inventor: Anthony O. Caggiano , Jennifer Iaci , Andrea Vecchione , Elizabeth Markensohn
- Applicant: Anthony O. Caggiano , Jennifer Iaci , Andrea Vecchione , Elizabeth Markensohn
- Applicant Address: US NY Ardsley
- Assignee: Acorda Therapeutics, Inc.
- Current Assignee: Acorda Therapeutics, Inc.
- Current Assignee Address: US NY Ardsley
- Agency: Pepper Hamilton LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/46 ; C12N9/88 ; C12N9/24 ; C12Q1/34 ; C07H21/04 ; C07K1/00
Abstract:
One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
Public/Granted literature
- US20100239557A1 COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS Public/Granted day:2010-09-23
Information query
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