An LED device with high color-rendering index includes a substrate; three white light units arranged on the substrate, each of the white light units being an LED element that combines a blue light chip with fluorescent glue to produce a mixed light; and a red light unit arranged on the substrate among the three white light units and being an LED element that combines a red light chip with fluorescent powder to produced a mixed light. With the specific arrangement of positioning the red light unit among three white light units, a mixed light produced by the LED device is a visually comfortable warm white light with high color-rendering index. Therefore, the LED device can be used in an environment where a large quantity of LEDs are needed, so largely reduces the users' eye discomfort.