A gradient compression article with therapeutic and aesthetic properties broadly includes a limb-receiving section extending continuously between a distal end and an open proximal end thereof. The limb-receiving section includes a tubular distal portion and a tubular proximal portion. The limb-receiving section is knitted at least substantially of a core-spun yarn with an elastomeric core and a twisted fiber sheath and includes elastomeric threads integrated into the stretch yarn knitting. The limb-receiving section further presents a gradient region that extends from a distal location adjacent the distal end to a proximal location adjacent the proximal end, with a property of the article changing progressively along the gradient region to provide compression that decreases progressively from the distal location to the proximal location when the article is donned.