An apparatus and method to translate virtual addresses to physical addresses in a base plus offset addressing mode are disclosed. In an embodiment, a method includes performing a first translation lookaside buffer (TLB) lookup based on a base address value to retrieve a speculative physical address. While performing the TLB lookup based on the base address value, the base address value is added to an offset value to generate an effective address value. The method also includes performing a comparison of the base address value and the effective address value based on a variable page size to determine whether the speculative physical address corresponds to the effective address.