A method for determining locations in a predefined area for placing a Radio Frequency Identification (RFID) reader in order to obtain a full coverage of the predefined area is provided. The method includes arranging a plurality of hexagonal area to form a combined area until the total area of the combined area is equal or larger than the predefined area, aligning the predefined area within the combined area, and determining the hexagonal area which is fully or partially covered by the predefined area. Each hexagonal area represents an area of coverage of the RFID reader, and the center of the hexagonal area which is determined to be fully or partially covered by the predefined area corresponds to one of the locations for placing the RFID reader.