A system and method for downlink control signal structure for multi-user MIMO is provided. A method comprises selecting a set of mobile stations (MSs) to receive substantially simultaneously transmitted transmissions, and transmitting interference control information and data to each mobile station (MS) in the set of MSs. A number of MSs in the set of MSs is less than a maximum allowable number of simultaneously scheduled MSs, and an amount of interference control information and a type of interference control information transmitted is based on the number of MSs in the set of MSs and the maximum allowable number of simultaneously scheduled MSs.