Methods and systems are described for assessing the results of a bioassay between probe biomolecules and target biomolecules using conventional optical disk drive. particular methods involve: bonding the probe biomolecules to a polycarbonate (PC) surface of an optical disk having digital data comprising error-detection redundancies recorded thereon: introducing the target biomolecules to the PC surface of the optical disk in a vicinity of the bonded probe biomolecules; processing the bioassay to alter a manner in which a read light from the optical disk interacts optically with the optical disk in a vicinity of positive bioassay results where the target biomolecules have bonded to the probe biomolecules; reading the digital data from the optical disk using the optical drive and using the error-redundancies to detect errors in the digital data read by the optical drive; mapping the detected errors to corresponding locations on the optical disk; and determining that positive bioassay results have occurred at the locations of the detected errors.