An image sensing system provides for accurate lens shading correction even when there is significant lens shading asymmetry and non-uniformity. A two-dimensional B-spline technique is used to determine lens shading correction surfaces. The number of zones is selected to achieve accurate correction of center, edge, and corner regions of an image. Separate lens shading correction surfaces are calculated for a set of standard illuminants to permit lens shading correction to be adapted based on the illuminant used to capture the image.