The invention relates to a method and a device for pseudo-differential transmission through interconnections used for sending a plurality of electrical signals.An interconnection having 4 transmission conductors and a return conductor distinct from the reference conductor cannot be modeled as a uniform multiconductor transmission line. Each end of the interconnection is connected to a termination circuit. Three damping circuits are connected between the return conductor and the reference conductor. The transmitting circuits receive at their inputs the signals from the 4 channels of the two sources, and are connected to the interconnection. The receiving circuits are connected to the interconnection, each receiving circuit being such that the signals of the 4 channels of a source connected to a transmitting circuit in the activated state are sent to the four channels of the destinations, without noticeable echo, internal crosstalk and external crosstalk.