Invention Grant
US08193379B2 Method for preparing 4B-amino-4′-demethyl-4-desoxypodophyllotoxin
有权
制备4B-氨基-4'-去甲基-4-脱氧鬼臼毒素的方法
- Patent Title: Method for preparing 4B-amino-4′-demethyl-4-desoxypodophyllotoxin
- Patent Title (中): 制备4B-氨基-4'-去甲基-4-脱氧鬼臼毒素的方法
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Application No.: US12894684Application Date: 2010-09-30
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Publication No.: US08193379B2Publication Date: 2012-06-05
- Inventor: Yves Guminski , Martial Grousseaud , Thierry Imbert
- Applicant: Yves Guminski , Martial Grousseaud , Thierry Imbert
- Applicant Address: FR Boulogne-Billancourt
- Assignee: Pierre Fabre Medicament
- Current Assignee: Pierre Fabre Medicament
- Current Assignee Address: FR Boulogne-Billancourt
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FR0507642 20050719
- Main IPC: C07D317/70
- IPC: C07D317/70
Abstract:
The invention relates to a method for synthesizing 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4β-halogenoacetamido-4′-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4β-amino-4′-demethyl-4-desoxypodophyllotoxin.
Public/Granted literature
- US20110021791A1 Method for preparing 4B-amino-4'-demethyl-4-desoxypodophyllotoxin Public/Granted day:2011-01-27
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