Invention Grant
- Patent Title: Heterocycle compound, and production process and application thereof
- Patent Title (中): 杂环化合物及其制备方法和应用
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Application No.: US11991858Application Date: 2006-09-15
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Publication No.: US08193356B2Publication Date: 2012-06-05
- Inventor: Hashime Kanazawa , Tomoji Aotsuka , Kentarou Kumazawa , Kouki Ishitani , Takashi Nose
- Applicant: Hashime Kanazawa , Tomoji Aotsuka , Kentarou Kumazawa , Kouki Ishitani , Takashi Nose
- Applicant Address: JP Tokyo
- Assignee: Aska Pharmaceutical Co., Ltd.
- Current Assignee: Aska Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-268527 20050915
- International Application: PCT/JP2006/318348 WO 20060915
- International Announcement: WO2007/032466 WO 20070322
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/437 ; A61P11/00 ; A61P11/06

Abstract:
The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.
Public/Granted literature
- US20090131467A1 Heterocycle Compound, and Production Process and Application Thereof Public/Granted day:2009-05-21
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